Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis
Identifieur interne : 000844 ( Main/Exploration ); précédent : 000843; suivant : 000845Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis
Auteurs : Tao-Tao Tang [République populaire de Chine] ; Lin-Li Lv [République populaire de Chine] ; Bin Wang [République populaire de Chine] ; Jing-Yuan Cao [République populaire de Chine] ; Ye Feng [République populaire de Chine] ; Zuo-Lin Li [République populaire de Chine] ; Min Wu [République populaire de Chine] ; Feng-Mei Wang [République populaire de Chine] ; Yi Wen [République populaire de Chine] ; Le-Ting Zhou [République populaire de Chine] ; Hai-Feng Ni [République populaire de Chine] ; Ping-Sheng Chen [République populaire de Chine] ; Ning Gu [République populaire de Chine] ; Steven D. Crowley [États-Unis] ; Bi-Cheng LiuSource :
- Theranostics [ 1838-7640 ] ; 2019.
Abstract
Although glucocorticoids are the mainstays in the treatment of renal diseases for decades, the dose dependent side effects have largely restricted their clinical use. Microvesicles (MVs) are small lipid-based membrane-bound particles generated by virtually all cells. Here we show that RAW 264.7 macrophage cell-derived MVs can be used as vectors to deliver dexamethasone (named as MV-DEX) targeting the inflamed kidney efficiently.
Url:
DOI: 10.7150/thno.33520
PubMed: 31367254
PubMed Central: 6643445
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis</title>
<author><name sortKey="Tang, Tao Tao" sort="Tang, Tao Tao" uniqKey="Tang T" first="Tao-Tao" last="Tang">Tao-Tao Tang</name>
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<author><name sortKey="Feng, Ye" sort="Feng, Ye" uniqKey="Feng Y" first="Ye" last="Feng">Ye Feng</name>
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<author><name sortKey="Li, Zuo Lin" sort="Li, Zuo Lin" uniqKey="Li Z" first="Zuo-Lin" last="Li">Zuo-Lin Li</name>
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<author><name sortKey="Wu, Min" sort="Wu, Min" uniqKey="Wu M" first="Min" last="Wu">Min Wu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
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<author><name sortKey="Wang, Feng Mei" sort="Wang, Feng Mei" uniqKey="Wang F" first="Feng-Mei" last="Wang">Feng-Mei Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing</wicri:regionArea>
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<author><name sortKey="Wen, Yi" sort="Wen, Yi" uniqKey="Wen Y" first="Yi" last="Wen">Yi Wen</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<wicri:noRegion>Nanjing</wicri:noRegion>
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<author><name sortKey="Zhou, Le Ting" sort="Zhou, Le Ting" uniqKey="Zhou L" first="Le-Ting" last="Zhou">Le-Ting Zhou</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing</wicri:regionArea>
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<author><name sortKey="Ni, Hai Feng" sort="Ni, Hai Feng" uniqKey="Ni H" first="Hai-Feng" last="Ni">Hai-Feng Ni</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
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<author><name sortKey="Chen, Ping Sheng" sort="Chen, Ping Sheng" uniqKey="Chen P" first="Ping-Sheng" last="Chen">Ping-Sheng Chen</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing</wicri:regionArea>
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<author><name sortKey="Gu, Ning" sort="Gu, Ning" uniqKey="Gu N" first="Ning" last="Gu">Ning Gu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
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<author><name sortKey="Crowley, Steven D" sort="Crowley, Steven D" uniqKey="Crowley S" first="Steven D." last="Crowley">Steven D. Crowley</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Bi Cheng" sort="Liu, Bi Cheng" uniqKey="Liu B" first="Bi-Cheng" last="Liu">Bi-Cheng Liu</name>
</author>
</analytic>
<series><title level="j">Theranostics</title>
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<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><p>Although glucocorticoids are the mainstays in the treatment of renal diseases for decades, the dose dependent side effects have largely restricted their clinical use. Microvesicles (MVs) are small lipid-based membrane-bound particles generated by virtually all cells. Here we show that RAW 264.7 macrophage cell-derived MVs can be used as vectors to deliver dexamethasone (named as MV-DEX) targeting the inflamed kidney efficiently.</p>
<p><bold>Methods</bold>
: RAW macrophages were incubated with dexamethasone and then MV-DEX was isolated from the supernatants by centrifugation method. Nanoparticle tracking analysis, transmission electron microscopy, western blot and high-performance liquid chromatography were used to analyze the properties of MV-DEX. The LC-MS/MS was applied to investigate the protein compositions of MV-DEX. Based on the murine models of LPS- or Adriamycin (ADR)-induced nephropathy or in-vitro culture of glomerular endothelial cells, the inflammation-targeting characteristics and the therapeutic efficacy of MV-DEX was examined. Finally, we assessed the side effects of chronic glucocorticoid therapy in MV-DEX-treated mice.</p>
<p><bold>Results</bold>
: Proteomic analysis revealed distinct integrin expression patterns on the MV-DEX surface, in which the integrin α<sub>L</sub>
β<sub>2</sub>
(LFA-1) and α<sub>4</sub>
β<sub>1</sub>
(VAL-4) enabled them to adhere to the inflamed kidney. Compared to free DEX treatment, equimolar doses of MV-DEX significantly attenuated renal injury with an enhanced therapeutic efficacy against renal inflammation and fibrosis in murine models of LPS- or ADR-induced nephropathy. <italic>In vitro</italic>
, MV-DEX with about one-fifth of the doses of free DEX achieved significant anti-inflammatory efficacy by inhibiting NF-κB activity. Mechanistically, MV-DEX could package and deliver glucocorticoid receptors to renal cells, thereby, increasing cellular levels of the receptor and improving cell sensitivity to glucocorticoids. Notably, delivering DEX in MVs significantly reduced the side effects of chronic glucocorticoid therapy (e.g., hyperglycemia, suppression of HPA axis).</p>
<p><bold>Conclusion</bold>
: In summary, macrophage-derived MVs efficiently deliver DEX into the inflamed kidney and exhibit a superior capacity to suppress renal inflammation and fibrosis without apparent glucocorticoid adverse effects. Our findings demonstrate the effectiveness and security of a novel drug delivery strategy with promising clinical applications.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ponticelli, C" uniqKey="Ponticelli C">C Ponticelli</name>
</author>
<author><name sortKey="Locatelli, F" uniqKey="Locatelli F">F Locatelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vandewalle, J" uniqKey="Vandewalle J">J Vandewalle</name>
</author>
<author><name sortKey="Luypaert, A" uniqKey="Luypaert A">A Luypaert</name>
</author>
<author><name sortKey="De Bosscher, K" uniqKey="De Bosscher K">K De Bosscher</name>
</author>
<author><name sortKey="Libert, C" uniqKey="Libert C">C Libert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stremersch, S" uniqKey="Stremersch S">S Stremersch</name>
</author>
<author><name sortKey="De Smedt, Sc" uniqKey="De Smedt S">SC De Smedt</name>
</author>
<author><name sortKey="Raemdonck, K" uniqKey="Raemdonck K">K Raemdonck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tkach, M" uniqKey="Tkach M">M Tkach</name>
</author>
<author><name sortKey="Thery, C" uniqKey="Thery C">C Théry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="Zhang, A" uniqKey="Zhang A">A Zhang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Klein, Jd" uniqKey="Klein J">JD Klein</name>
</author>
<author><name sortKey="Tan, L" uniqKey="Tan L">L Tan</name>
</author>
<author><name sortKey="Wang, Zm" uniqKey="Wang Z">ZM Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Andaloussi, S" uniqKey="El Andaloussi S">S EL Andaloussi</name>
</author>
<author><name sortKey="M Ger, I" uniqKey="M Ger I">I Mäger</name>
</author>
<author><name sortKey="Breakefield, Xo" uniqKey="Breakefield X">XO Breakefield</name>
</author>
<author><name sortKey="Wood, Mj" uniqKey="Wood M">MJ Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Wu, Wj" uniqKey="Wu W">WJ Wu</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Li, Zl" uniqKey="Li Z">ZL Li</name>
</author>
<author><name sortKey="Tang, Tt" uniqKey="Tang T">TT Tang</name>
</author>
<author><name sortKey="Liu, Bc" uniqKey="Liu B">BC Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fais, S" uniqKey="Fais S">S Fais</name>
</author>
<author><name sortKey="O Driscoll, L" uniqKey="O Driscoll L">L O'Driscoll</name>
</author>
<author><name sortKey="Borras, Fe" uniqKey="Borras F">FE Borras</name>
</author>
<author><name sortKey="Buzas, E" uniqKey="Buzas E">E Buzas</name>
</author>
<author><name sortKey="Camussi, G" uniqKey="Camussi G">G Camussi</name>
</author>
<author><name sortKey="Cappello, F" uniqKey="Cappello F">F Cappello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, K" uniqKey="Tang K">K Tang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Xu, P" uniqKey="Xu P">P Xu</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, T" uniqKey="Yang T">T Yang</name>
</author>
<author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name>
</author>
<author><name sortKey="Fogarty, B" uniqKey="Fogarty B">B Fogarty</name>
</author>
<author><name sortKey="Brown, A" uniqKey="Brown A">A Brown</name>
</author>
<author><name sortKey="Schurman, K" uniqKey="Schurman K">K Schurman</name>
</author>
<author><name sortKey="Phipps, R" uniqKey="Phipps R">R Phipps</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y Wan</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Zhu, C" uniqKey="Zhu C">C Zhu</name>
</author>
<author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q Zheng</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Tong, J" uniqKey="Tong J">J Tong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamerkar, S" uniqKey="Kamerkar S">S Kamerkar</name>
</author>
<author><name sortKey="Lebleu, Vs" uniqKey="Lebleu V">VS LeBleu</name>
</author>
<author><name sortKey="Sugimoto, H" uniqKey="Sugimoto H">H Sugimoto</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Ruivo, Cf" uniqKey="Ruivo C">CF Ruivo</name>
</author>
<author><name sortKey="Melo, Sa" uniqKey="Melo S">SA Melo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alvarez Erviti, L" uniqKey="Alvarez Erviti L">L Alvarez-Erviti</name>
</author>
<author><name sortKey="Seow, Y" uniqKey="Seow Y">Y Seow</name>
</author>
<author><name sortKey="Yin, H" uniqKey="Yin H">H Yin</name>
</author>
<author><name sortKey="Betts, C" uniqKey="Betts C">C Betts</name>
</author>
<author><name sortKey="Lakhal, S" uniqKey="Lakhal S">S Lakhal</name>
</author>
<author><name sortKey="Wood, Mj" uniqKey="Wood M">MJ Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jc Bose, R" uniqKey="Jc Bose R">R Jc Bose</name>
</author>
<author><name sortKey="Uday Kumar, S" uniqKey="Uday Kumar S">S Uday Kumar</name>
</author>
<author><name sortKey="Zeng, Y" uniqKey="Zeng Y">Y Zeng</name>
</author>
<author><name sortKey="Afjei, R" uniqKey="Afjei R">R Afjei</name>
</author>
<author><name sortKey="Robinson, E" uniqKey="Robinson E">E Robinson</name>
</author>
<author><name sortKey="Lau, K" uniqKey="Lau K">K Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name>
</author>
<author><name sortKey="Zhuang, X" uniqKey="Zhuang X">X Zhuang</name>
</author>
<author><name sortKey="Xiang, X" uniqKey="Xiang X">X Xiang</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhuang, X" uniqKey="Zhuang X">X Zhuang</name>
</author>
<author><name sortKey="Xiang, X" uniqKey="Xiang X">X Xiang</name>
</author>
<author><name sortKey="Grizzle, W" uniqKey="Grizzle W">W Grizzle</name>
</author>
<author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Axtell, Rc" uniqKey="Axtell R">RC Axtell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamaly, N" uniqKey="Kamaly N">N Kamaly</name>
</author>
<author><name sortKey="He, Jc" uniqKey="He J">JC He</name>
</author>
<author><name sortKey="Ausiello, Da" uniqKey="Ausiello D">DA Ausiello</name>
</author>
<author><name sortKey="Farokhzad, Oc" uniqKey="Farokhzad O">OC Farokhzad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dolman, Me" uniqKey="Dolman M">ME Dolman</name>
</author>
<author><name sortKey="Harmsen, S" uniqKey="Harmsen S">S Harmsen</name>
</author>
<author><name sortKey="Storm, G" uniqKey="Storm G">G Storm</name>
</author>
<author><name sortKey="Hennink, We" uniqKey="Hennink W">WE Hennink</name>
</author>
<author><name sortKey="Kok, Rj" uniqKey="Kok R">RJ Kok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Ran, N" uniqKey="Ran N">N Ran</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
<author><name sortKey="Zuo, B" uniqKey="Zuo B">B Zuo</name>
</author>
<author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name>
</author>
<author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuhrmann, G" uniqKey="Fuhrmann G">G Fuhrmann</name>
</author>
<author><name sortKey="Herrmann, Ik" uniqKey="Herrmann I">IK Herrmann</name>
</author>
<author><name sortKey="Stevens, Mm" uniqKey="Stevens M">MM Stevens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, D" uniqKey="Yuan D">D Yuan</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Banks, Wa" uniqKey="Banks W">WA Banks</name>
</author>
<author><name sortKey="Bullock, Km" uniqKey="Bullock K">KM Bullock</name>
</author>
<author><name sortKey="Haney, M" uniqKey="Haney M">M Haney</name>
</author>
<author><name sortKey="Batrakova, E" uniqKey="Batrakova E">E Batrakova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meng, Xm" uniqKey="Meng X">XM Meng</name>
</author>
<author><name sortKey="Nikolic Paterson, Dj" uniqKey="Nikolic Paterson D">DJ Nikolic-Paterson</name>
</author>
<author><name sortKey="Lan, Hy" uniqKey="Lan H">HY Lan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Bc" uniqKey="Liu B">BC Liu</name>
</author>
<author><name sortKey="Tang, Tt" uniqKey="Tang T">TT Tang</name>
</author>
<author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Lan, Hy" uniqKey="Lan H">HY Lan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, Jb" uniqKey="Hu J">JB Hu</name>
</author>
<author><name sortKey="Kang, Xq" uniqKey="Kang X">XQ Kang</name>
</author>
<author><name sortKey="Liang, J" uniqKey="Liang J">J Liang</name>
</author>
<author><name sortKey="Wang, Xj" uniqKey="Wang X">XJ Wang</name>
</author>
<author><name sortKey="Xu, Xl" uniqKey="Xu X">XL Xu</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mallipattu, Sk" uniqKey="Mallipattu S">SK Mallipattu</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="Revelo, Mp" uniqKey="Revelo M">MP Revelo</name>
</author>
<author><name sortKey="Roa Pe A, L" uniqKey="Roa Pe A L">L Roa-Peña</name>
</author>
<author><name sortKey="Miller, T" uniqKey="Miller T">T Miller</name>
</author>
<author><name sortKey="Ling, J" uniqKey="Ling J">J Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rops, Al" uniqKey="Rops A">AL Rops</name>
</author>
<author><name sortKey="Van Der Vlag, J" uniqKey="Van Der Vlag J">J van der Vlag</name>
</author>
<author><name sortKey="Jacobs, Cw" uniqKey="Jacobs C">CW Jacobs</name>
</author>
<author><name sortKey="Dijkman, Hb" uniqKey="Dijkman H">HB Dijkman</name>
</author>
<author><name sortKey="Lensen, Jf" uniqKey="Lensen J">JF Lensen</name>
</author>
<author><name sortKey="Wijnhoven, Tj" uniqKey="Wijnhoven T">TJ Wijnhoven</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reiser, J" uniqKey="Reiser J">J Reiser</name>
</author>
<author><name sortKey="Von Gersdorff, G" uniqKey="Von Gersdorff G">G von Gersdorff</name>
</author>
<author><name sortKey="Loos, M" uniqKey="Loos M">M Loos</name>
</author>
<author><name sortKey="Oh, J" uniqKey="Oh J">J Oh</name>
</author>
<author><name sortKey="Asanuma, K" uniqKey="Asanuma K">K Asanuma</name>
</author>
<author><name sortKey="Giardino, L" uniqKey="Giardino L">L Giardino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hahm, E" uniqKey="Hahm E">E Hahm</name>
</author>
<author><name sortKey="Wei, C" uniqKey="Wei C">C Wei</name>
</author>
<author><name sortKey="Fernandez, I" uniqKey="Fernandez I">I Fernandez</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Tardi, Nj" uniqKey="Tardi N">NJ Tardi</name>
</author>
<author><name sortKey="Tracy, M" uniqKey="Tracy M">M Tracy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gangadaran, P" uniqKey="Gangadaran P">P Gangadaran</name>
</author>
<author><name sortKey="Hong, Cm" uniqKey="Hong C">CM Hong</name>
</author>
<author><name sortKey="Ahn, Bc" uniqKey="Ahn B">BC Ahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawakami, T" uniqKey="Kawakami T">T Kawakami</name>
</author>
<author><name sortKey="Gomez, Ig" uniqKey="Gomez I">IG Gomez</name>
</author>
<author><name sortKey="Ren, S" uniqKey="Ren S">S Ren</name>
</author>
<author><name sortKey="Hudkins, K" uniqKey="Hudkins K">K Hudkins</name>
</author>
<author><name sortKey="Roach, A" uniqKey="Roach A">A Roach</name>
</author>
<author><name sortKey="Alpers, Ce" uniqKey="Alpers C">CE Alpers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sung, Ms" uniqKey="Sung M">MS Sung</name>
</author>
<author><name sortKey="Jung, Jh" uniqKey="Jung J">JH Jung</name>
</author>
<author><name sortKey="Jeong, C" uniqKey="Jeong C">C Jeong</name>
</author>
<author><name sortKey="Yoon, Ty" uniqKey="Yoon T">TY Yoon</name>
</author>
<author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kowal, J" uniqKey="Kowal J">J Kowal</name>
</author>
<author><name sortKey="Arras, G" uniqKey="Arras G">G Arras</name>
</author>
<author><name sortKey="Colombo, M" uniqKey="Colombo M">M Colombo</name>
</author>
<author><name sortKey="Jouve, M" uniqKey="Jouve M">M Jouve</name>
</author>
<author><name sortKey="Morath, Jp" uniqKey="Morath J">JP Morath</name>
</author>
<author><name sortKey="Primdal Bengtson, B" uniqKey="Primdal Bengtson B">B Primdal-Bengtson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imhof, Ba" uniqKey="Imhof B">BA Imhof</name>
</author>
<author><name sortKey="Aurrand Lions, M" uniqKey="Aurrand Lions M">M Aurrand-Lions</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szekanecz, Z" uniqKey="Szekanecz Z">Z Szekanecz</name>
</author>
<author><name sortKey="Koch, Ae" uniqKey="Koch A">AE Koch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Wen, Y" uniqKey="Wen Y">Y Wen</name>
</author>
<author><name sortKey="Wu, Wj" uniqKey="Wu W">WJ Wu</name>
</author>
<author><name sortKey="Ni, Hf" uniqKey="Ni H">HF Ni</name>
</author>
<author><name sortKey="Li, Zl" uniqKey="Li Z">ZL Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Tang, Pm" uniqKey="Tang P">PM Tang</name>
</author>
<author><name sortKey="Li, Cj" uniqKey="Li C">CJ Li</name>
</author>
<author><name sortKey="You, Yk" uniqKey="You Y">YK You</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Huang, Xr" uniqKey="Huang X">XR Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desmet, Sj" uniqKey="Desmet S">SJ Desmet</name>
</author>
<author><name sortKey="De Bosscher, K" uniqKey="De Bosscher K">K De Bosscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, K" uniqKey="Yan K">K Yan</name>
</author>
<author><name sortKey="Kudo, A" uniqKey="Kudo A">A Kudo</name>
</author>
<author><name sortKey="Hirano, H" uniqKey="Hirano H">H Hirano</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Tasaka, T" uniqKey="Tasaka T">T Tasaka</name>
</author>
<author><name sortKey="Kataoka, S" uniqKey="Kataoka S">S Kataoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johanssen, S" uniqKey="Johanssen S">S Johanssen</name>
</author>
<author><name sortKey="Allolio, B" uniqKey="Allolio B">B Allolio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xue, Q" uniqKey="Xue Q">Q Xue</name>
</author>
<author><name sortKey="Dasgupta, C" uniqKey="Dasgupta C">C Dasgupta</name>
</author>
<author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vilaysane, A" uniqKey="Vilaysane A">A Vilaysane</name>
</author>
<author><name sortKey="Chun, J" uniqKey="Chun J">J Chun</name>
</author>
<author><name sortKey="Seamone, Me" uniqKey="Seamone M">ME Seamone</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Chin, R" uniqKey="Chin R">R Chin</name>
</author>
<author><name sortKey="Hirota, S" uniqKey="Hirota S">S Hirota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name>
</author>
<author><name sortKey="Wen, Y" uniqKey="Wen Y">Y Wen</name>
</author>
<author><name sortKey="Tang, Tt" uniqKey="Tang T">TT Tang</name>
</author>
<author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Tang, Rn" uniqKey="Tang R">RN Tang</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Tt" uniqKey="Tang T">TT Tang</name>
</author>
<author><name sortKey="Lv, Ll" uniqKey="Lv L">LL Lv</name>
</author>
<author><name sortKey="Pan, Mm" uniqKey="Pan M">MM Pan</name>
</author>
<author><name sortKey="Wen, Y" uniqKey="Wen Y">Y Wen</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="Li, Zl" uniqKey="Li Z">ZL Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paugh, Sw" uniqKey="Paugh S">SW Paugh</name>
</author>
<author><name sortKey="Bonten, Ej" uniqKey="Bonten E">EJ Bonten</name>
</author>
<author><name sortKey="Savic, D" uniqKey="Savic D">D Savic</name>
</author>
<author><name sortKey="Ramsey, Lb" uniqKey="Ramsey L">LB Ramsey</name>
</author>
<author><name sortKey="Thierfelder, We" uniqKey="Thierfelder W">WE Thierfelder</name>
</author>
<author><name sortKey="Gurung, P" uniqKey="Gurung P">P Gurung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robert, O" uniqKey="Robert O">O Robert</name>
</author>
<author><name sortKey="Boujedidi, H" uniqKey="Boujedidi H">H Boujedidi</name>
</author>
<author><name sortKey="Bigorgne, A" uniqKey="Bigorgne A">A Bigorgne</name>
</author>
<author><name sortKey="Ferrere, G" uniqKey="Ferrere G">G Ferrere</name>
</author>
<author><name sortKey="Voican, Cs" uniqKey="Voican C">CS Voican</name>
</author>
<author><name sortKey="Vettorazzi, S" uniqKey="Vettorazzi S">S Vettorazzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Wu, W" uniqKey="Wu W">W Wu</name>
</author>
<author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name>
</author>
<author><name sortKey="Huang, D" uniqKey="Huang D">D Huang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bilkova, E" uniqKey="Bilkova E">E Bílková</name>
</author>
<author><name sortKey="Imramovsk, A" uniqKey="Imramovsk A">A Imramovský</name>
</author>
<author><name sortKey="Sedlak, M" uniqKey="Sedlak M">M Sedlák</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aqil, F" uniqKey="Aqil F">F Aqil</name>
</author>
<author><name sortKey="Kausar, H" uniqKey="Kausar H">H Kausar</name>
</author>
<author><name sortKey="Agrawal, Ak" uniqKey="Agrawal A">AK Agrawal</name>
</author>
<author><name sortKey="Jeyabalan, J" uniqKey="Jeyabalan J">J Jeyabalan</name>
</author>
<author><name sortKey="Kyakulaga, Ah" uniqKey="Kyakulaga A">AH Kyakulaga</name>
</author>
<author><name sortKey="Munagala, R" uniqKey="Munagala R">R Munagala</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
</list>
<tree><noCountry><name sortKey="Liu, Bi Cheng" sort="Liu, Bi Cheng" uniqKey="Liu B" first="Bi-Cheng" last="Liu">Bi-Cheng Liu</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Tang, Tao Tao" sort="Tang, Tao Tao" uniqKey="Tang T" first="Tao-Tao" last="Tang">Tao-Tao Tang</name>
</noRegion>
<name sortKey="Cao, Jing Yuan" sort="Cao, Jing Yuan" uniqKey="Cao J" first="Jing-Yuan" last="Cao">Jing-Yuan Cao</name>
<name sortKey="Chen, Ping Sheng" sort="Chen, Ping Sheng" uniqKey="Chen P" first="Ping-Sheng" last="Chen">Ping-Sheng Chen</name>
<name sortKey="Feng, Ye" sort="Feng, Ye" uniqKey="Feng Y" first="Ye" last="Feng">Ye Feng</name>
<name sortKey="Gu, Ning" sort="Gu, Ning" uniqKey="Gu N" first="Ning" last="Gu">Ning Gu</name>
<name sortKey="Li, Zuo Lin" sort="Li, Zuo Lin" uniqKey="Li Z" first="Zuo-Lin" last="Li">Zuo-Lin Li</name>
<name sortKey="Lv, Lin Li" sort="Lv, Lin Li" uniqKey="Lv L" first="Lin-Li" last="Lv">Lin-Li Lv</name>
<name sortKey="Ni, Hai Feng" sort="Ni, Hai Feng" uniqKey="Ni H" first="Hai-Feng" last="Ni">Hai-Feng Ni</name>
<name sortKey="Wang, Bin" sort="Wang, Bin" uniqKey="Wang B" first="Bin" last="Wang">Bin Wang</name>
<name sortKey="Wang, Feng Mei" sort="Wang, Feng Mei" uniqKey="Wang F" first="Feng-Mei" last="Wang">Feng-Mei Wang</name>
<name sortKey="Wen, Yi" sort="Wen, Yi" uniqKey="Wen Y" first="Yi" last="Wen">Yi Wen</name>
<name sortKey="Wu, Min" sort="Wu, Min" uniqKey="Wu M" first="Min" last="Wu">Min Wu</name>
<name sortKey="Zhou, Le Ting" sort="Zhou, Le Ting" uniqKey="Zhou L" first="Le-Ting" last="Zhou">Le-Ting Zhou</name>
</country>
<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Crowley, Steven D" sort="Crowley, Steven D" uniqKey="Crowley S" first="Steven D." last="Crowley">Steven D. Crowley</name>
</region>
</country>
</tree>
</affiliations>
</record>
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